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Syphilis

A Resurgent Infection: Early Detection is Critical

Syphilis cases have increased dramatically in recent years. Often called 'the great imitator', it can mimic other conditions. Early treatment with penicillin is curative. Don't delay testing.

What is Syphilis?

Syphilis is a bacterial infection caused by Treponema pallidum. Once declining, cases have risen significantly in recent years, particularly among men who have sex with men. Syphilis progresses through distinct stages if untreated and can eventually affect the heart, brain, and other organs. The good news: it's easily curable with penicillin, especially when caught early.

Symptoms

  • PRIMARY: Painless sore (chancre) at infection site, 10-90 days after exposure
  • Chancre heals on its own after 3-6 weeks WITHOUT treatment
  • SECONDARY: Body rash (often palms and soles), fever, swollen lymph nodes
  • Secondary symptoms: Hair loss, white patches in mouth, fatigue
  • LATENT: No symptoms but still infected and detectable by blood test
  • TERTIARY: Serious damage to heart, brain, nerves (years later if untreated)
  • Symptoms can be subtle or mistaken for other conditions

Causes

  • Infection with Treponema pallidum bacteria
  • Direct contact with a syphilis sore (chancre) during sex
  • Vaginal, anal, or oral sex with infected partner
  • Sores often in hidden locations (rectum, cervix, mouth)
  • Mother-to-baby transmission (congenital syphilis)
  • Very rarely through blood transfusion or sharing needles
  • NOT spread through toilet seats, sharing food, or casual contact

Who Is at Risk?

  • Men who have sex with men (highest rates)
  • People living with HIV
  • People with multiple sexual partners
  • Those not using condoms consistently
  • Partners of people with syphilis
  • People who exchange sex for money or drugs

Potential Complications

  • Neurosyphilis (brain and spinal cord involvement)
  • Cardiovascular syphilis (heart and blood vessel damage)
  • Gummatous syphilis (destructive lesions in organs)
  • Increased risk of HIV transmission (3-5 fold increase)
  • Congenital syphilis in babies (serious birth defects, stillbirth)
  • Blindness, dementia, paralysis in late-stage disease

How We Diagnose

Syphilis is diagnosed through blood tests that detect antibodies. Screening tests (EIA/CLIA) detect recent or past infection. If positive, confirmatory tests determine if infection is active. The window period is 1-3 weeks for EIA tests. During primary stage, sores can be swabbed for PCR testing. Regular screening is recommended for those at ongoing risk.

Treatment Options

Syphilis is treated with penicillin injection(s). Early syphilis (primary, secondary, early latent) usually requires a single injection. Late latent or unknown duration requires three weekly injections. Alternative antibiotics are available for those allergic to penicillin (though penicillin desensitisation may be preferred). Treatment cures the infection but doesn't reverse any damage already done.

Prevention

Consistent condom use (though sores may be in uncovered areas)
Regular STI screening if at risk
Testing and treatment of sexual partners
Reducing number of sexual partners
Open communication about STI status
Avoiding sex until treatment is complete

Frequently Asked Questions

Can syphilis be cured?

Yes! Syphilis is completely curable with appropriate antibiotic treatment, usually penicillin. Treatment kills the bacteria and prevents progression, but cannot reverse damage already done. This is why early detection and treatment are so important.

I had a painless sore that went away - do I still need to test?

Absolutely. The primary chancre of syphilis is characteristically painless and heals on its own - but this doesn't mean you're cured. The infection progresses to secondary and then latent stages. A blood test can detect the infection even after the sore has healed.

How often should I test for syphilis?

If you're at ongoing risk (multiple partners, MSM, HIV-positive), testing every 3 months is recommended. Others should test annually if sexually active with multiple partners, with each new partner, or if you develop symptoms. Testing is a simple blood test.

Can I get syphilis again after treatment?

Yes. Treatment cures your current infection but doesn't provide immunity. You can be reinfected if exposed again. Partners must also be tested and treated to prevent 'ping-pong' reinfection between partners.

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