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Urethritis

Urethral Inflammation Requiring Investigation

Urethritis causes painful urination and discharge. Most commonly caused by STIs, it requires proper testing to identify the cause and guide effective treatment. Both men and women can be affected.

What is Urethritis?

Urethritis is inflammation of the urethra - the tube that carries urine from the bladder. It causes pain, burning, and often discharge. In sexually active people, urethritis is usually caused by sexually transmitted infections, most commonly chlamydia and gonorrhoea. Proper testing identifies the specific cause, which is essential for appropriate treatment. Untreated urethritis can lead to complications.

Symptoms

  • Pain or burning when urinating
  • Discharge from urethra (clear, white, yellow, or green)
  • Urethral itching or irritation
  • Increased urinary frequency
  • Blood in urine or semen (less common)
  • Discomfort at tip of penis
  • Women: may have fewer symptoms or mistaken for UTI

Causes

  • Gonorrhoea (gonococcal urethritis)
  • Chlamydia (most common cause of non-gonococcal urethritis)
  • Mycoplasma genitalium
  • Ureaplasma urealyticum
  • Trichomonas vaginalis
  • Herpes simplex virus
  • Non-infectious causes (trauma, irritants, catheters)
  • Reactive urethritis (non-infectious, associated with other conditions)

Who Is at Risk?

  • Sexually active individuals
  • People with new or multiple sexual partners
  • People who don't use condoms consistently
  • Men who have sex with men
  • Young adults (highest incidence)
  • Anyone with partners who have STIs

Potential Complications

  • Epididymitis (infection of epididymis) in men
  • Orchitis (testicular infection)
  • Prostatitis
  • Urethral stricture (scarring)
  • Spread to partners
  • Women: cervicitis, PID, infertility risk
  • Reactive arthritis (rare)

How We Diagnose

We test urine and/or urethral swabs for gonorrhoea, chlamydia, and other pathogens using PCR. Microscopy can detect inflammation. We distinguish between gonococcal urethritis (caused by gonorrhoea) and non-gonococcal urethritis (NGU, caused by other organisms). Testing for M. genitalium is important if standard tests are negative. Full STI screening is recommended.

Treatment Options

Treatment depends on the cause. Gonorrhoea requires specific antibiotics (often injection plus oral). Chlamydia is treated with doxycycline. M. genitalium needs resistance-guided treatment. Empirical treatment may start before results if symptoms are significant. Partners need testing and treatment. Avoid sex until treatment completed and symptoms resolved.

Prevention

Consistent condom use
Regular STI testing, especially with new partners
Prompt treatment of infections
Partner notification and testing
Avoid sex until treatment completed
Return if symptoms persist or recur

Frequently Asked Questions

Is urethritis always sexually transmitted?

In sexually active people, urethritis is usually caused by STIs. However, non-infectious causes exist including trauma, chemical irritation, catheter use, and reactive urethritis. If STI tests are negative but symptoms persist, we investigate other causes. Your sexual history helps guide our approach.

What's the difference between urethritis and a UTI?

Urethritis is inflammation of the urethra, often from STIs. UTIs (urinary tract infections) are bacterial infections of the bladder/urinary system, usually caused by gut bacteria like E. coli. UTIs are more common in women. Symptoms overlap, so testing distinguishes them. Treatment differs depending on the cause.

Can women get urethritis?

Yes, women can have urethritis, though it's diagnosed less often because symptoms may be milder or attributed to other conditions. Chlamydia and gonorrhoea can infect the female urethra. Women with urinary symptoms and STI risk should be tested for both UTIs and STIs.

Why does my urethritis keep coming back?

Recurrent urethritis is usually due to: reinfection from untreated partners, infection with resistant organisms (especially M. genitalium), incomplete treatment, or a different organism not covered by initial treatment. Persistent cases need comprehensive testing and partner management. We can investigate thoroughly.

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