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Hepatitis B

A Serious but Vaccine-Preventable Infection

Hepatitis B is 50-100 times more infectious than HIV. It can cause chronic liver disease, but is entirely preventable through vaccination. Early detection and monitoring are crucial for long-term health.

What is Hepatitis B?

Hepatitis B is a potentially serious viral infection affecting the liver, transmitted through blood and body fluids including sexual contact. While many adults clear the infection naturally, about 5-10% develop chronic Hepatitis B which can lead to cirrhosis and liver cancer. Effective vaccination has been available since 1982, making this a vaccine-preventable disease.

Symptoms

  • Many people have no symptoms initially
  • Fatigue and weakness
  • Loss of appetite
  • Nausea and vomiting
  • Abdominal pain
  • Dark urine
  • Jaundice (yellowing of skin and eyes)
  • Joint pain
  • Fever
  • Symptoms appear 1-4 months after exposure

Causes

  • Sexual contact with infected person
  • Sharing needles or drug equipment
  • Mother-to-baby transmission during birth
  • Needlestick injuries (healthcare workers)
  • Sharing razors or toothbrushes with blood contact
  • Unsterilised tattooing or piercing equipment
  • Blood transfusion (now rare due to screening)
  • The virus survives outside the body for 7+ days

Who Is at Risk?

  • People with multiple sexual partners
  • Men who have sex with men
  • People who inject drugs
  • Healthcare workers
  • Sexual partners of infected individuals
  • Babies born to infected mothers
  • People from endemic regions (Asia, Africa, Pacific Islands)
  • People with HIV or Hepatitis C
  • Haemodialysis patients

Potential Complications

  • Chronic hepatitis B (5-10% of adults)
  • Liver cirrhosis
  • Liver cancer (hepatocellular carcinoma)
  • Liver failure
  • Kidney disease (glomerulonephritis)
  • Blood vessel inflammation (vasculitis)
  • Higher complications if co-infected with HIV or Hepatitis C

How We Diagnose

Hepatitis B testing involves blood tests for surface antigen (HBsAg) which indicates current infection, and antibodies (anti-HBs, anti-HBc) showing past infection or immunity. We recommend a full hepatitis B panel to understand your status. Additional tests may include viral load and liver function tests for those with chronic infection.

Treatment Options

Acute Hepatitis B usually resolves without specific treatment - supportive care includes rest, hydration, and avoiding alcohol. Chronic Hepatitis B may require long-term antiviral medications (entecavir, tenofovir) to suppress the virus and prevent liver damage. Regular monitoring of liver function and viral load is essential. Some patients may need hepatology care.

Prevention

Hepatitis B vaccination (3-dose course)
Use condoms for sexual contact
Never share needles or drug equipment
Ensure sterile equipment for tattoos/piercings
Test during pregnancy for mother-to-baby prevention
Vaccination after exposure may help—contact NHS services
Regular testing if at ongoing risk

Frequently Asked Questions

What's the difference between acute and chronic Hepatitis B?

Acute Hepatitis B is a short-term infection in the first 6 months after exposure - most adults clear this naturally. Chronic Hepatitis B is when the infection persists beyond 6 months. About 5-10% of infected adults, but up to 90% of infected infants, develop chronic infection.

Can Hepatitis B be cured?

Acute Hepatitis B often clears naturally. Chronic Hepatitis B cannot currently be cured but can be controlled with antiviral medications. A 'functional cure' where the virus becomes undetectable is possible in some cases. Research into curative treatments continues.

Should I get vaccinated if I've been exposed?

Yes - vaccination after exposure (with possibly immunoglobulin) can prevent infection if given within 24-48 hours of exposure. Contact an NHS sexual health clinic or A&E immediately if you've had a potential exposure. Even after 7 days, vaccination may still help.

Can I transmit Hepatitis B to my partner?

Yes, if you have active Hepatitis B (HBsAg positive) you can transmit it sexually. Your partner should be tested and vaccinated if not immune. Using condoms reduces but doesn't eliminate risk. Once your partner is immune (confirmed by antibody test), transmission risk is negligible.

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