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What is Mpox (Monkeypox)?
Mpox (formerly monkeypox) is a viral infection causing a distinctive rash that progresses through stages before healing. The 2022 global outbreak involved a different transmission pattern than historically seen in Africa, spreading primarily through close physical contact including sexual contact, particularly among men who have sex with men. Most cases are mild and self-limiting, but the rash can be painful and leave scars.
Symptoms
- Rash: progresses from flat spots to raised bumps to fluid-filled blisters to pustules to scabs
- Rash may start on or near genitals, anus, or mouth
- Fever and chills
- Swollen lymph nodes (distinctive feature)
- Headache and muscle aches
- Fatigue
- Rectal pain (proctitis) in some cases
- Symptoms appear 5-21 days after exposure
- Illness typically lasts 2-4 weeks
Causes
- Mpox virus (Orthopoxvirus family)
- Close skin-to-skin contact with infected person
- Contact with rash, scabs, or body fluids
- Sexual contact (significant transmission route in current outbreak)
- Prolonged face-to-face contact
- Contact with contaminated materials (bedding, towels)
- Respiratory secretions during prolonged close contact
Who Is at Risk?
- Men who have sex with men with multiple partners
- Sexual partners of people with mpox
- People who attend venues where intimate contact occurs
- Healthcare workers caring for mpox patients
- Laboratory workers handling specimens
- People with HIV or immunosuppression (higher complication risk)
- Close household contacts of infected individuals
Potential Complications
- Painful rash, especially anal or genital lesions
- Secondary bacterial skin infection
- Scarring
- Proctitis (rectal inflammation)
- Eye involvement if virus spreads to eyes
- Pneumonia (rare)
- Encephalitis (rare)
- More severe in immunocompromised individuals
How We Diagnose
Mpox is diagnosed by PCR testing of lesion swabs - samples are taken from the rash itself. If you have a new rash with mpox-like features, contact us for assessment. Clinical evaluation is important as mpox can resemble other conditions. Testing should be done early in the illness when virus is most detectable.
Treatment Options
Most mpox cases are managed with supportive care: pain relief, keeping lesions clean and dry, and rest. Severe cases or those at high risk of complications may receive antiviral medication (tecovirimat). Proctitis may require specific management. Isolate until all lesions have healed and scabs have fallen off. This typically takes 2-4 weeks.
Prevention
Frequently Asked Questions
Who is eligible for mpox vaccination?
In the UK, vaccination is offered to gay, bisexual, and other men who have sex with men at higher risk - typically those with multiple partners. Healthcare workers at high risk are also eligible. If you think you'd benefit from vaccination, discuss with us. Post-exposure vaccination can help if given within 4 days of exposure.
How is mpox different from chickenpox or STIs causing rashes?
Mpox rash has distinctive stages and usually involves swollen lymph nodes. Unlike chickenpox, lesions are typically in the same stage. Unlike herpes, mpox causes deeper, more widespread lesions. Professional assessment is needed as several conditions can cause genital rashes. We can test to confirm the diagnosis.
How long am I infectious with mpox?
You're infectious from when symptoms start until all lesions have completely healed and fresh skin has formed - typically 2-4 weeks. You should isolate during this time. Even with mild symptoms, you can transmit the virus. Scabs contain virus so avoid contact until they've fallen off naturally.
Can I get mpox again after recovery?
Reinfection appears uncommon as infection provides some immunity. However, the degree and duration of protection is still being studied. Even after recovery, vaccination may be recommended depending on your risk factors. Continue preventive measures during outbreaks.
Concerned About Mpox (Monkeypox)?
Book a confidential consultation or STI test at our South Kensington clinic. Walk-in appointments available.



